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CREB-Binding-Protein

CREB-Binding-Protein

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Vorhandene Strukturdaten: s. UniProt
Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 2442 Aminosäuren
Bezeichner
Gen-Name CREBBP
Externe IDs OMIM: 600140 UniProt: Q92793
Enzymklassifikation
EC, Kategorie 2.3.1.48  Acetyltransferase
Reaktionsart Übertragung einer Acetylgruppe
Substrat Histon + Acetyl-CoA
Produkte Acetylhiston + CoA
Vorkommen
Homologie-Familie CREBBP
Übergeordnetes Taxon Euteleostomi

Das CREB-Binding Protein (CREB-Bindeprotein), kurz CBP, ist ein Coaktivator der Transkription.

CBP stellt eine Verbindung zwischen dem Transkriptionsfaktor CREB und dem Transkriptionsstartpunkt her, indem es als Histon-Acetyltransferase (HAT, EC 2.3.1.48) die Chromatin-Struktur verändert, die dadurch aufgelockert wird. CBP zeigt Homologien zum ebenfalls als HAT wirkendem Protein p300. CBP und p300 acetylieren bevorzugt die Histone H3 und H4.

CBP ist ein Coaktivator allgemeiner Natur und wechselwirkt z. B. auch mit Transkriptionsfaktoren.

Klinische Bedeutung

Mutationen in diesem Gen sind für das Rubinstein-Taybi-Syndrom (RTS) verantwortlich.[1]

Interaktionen

Das CREB-Bindeprotein weist Interaktion mit folgenden Proteinen auf:

Siehe auch

Einzelnachweise

  1. ↑ Petrij F, Giles RH, Dauwerse HG, Saris JJ, Hennekam RC, Masuno M, Tommerup N, van Ommen GJ, Goodman RH, Peters DJ: Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP. In: Nature. 376. Jahrgang, Nr. 6538, Juli 1995, S. 348–51, doi:10.1038/376348a0, PMID 7630403, bibcode:1995Natur.376..348P.
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